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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophyto enable them to continue their activities at an optimum level throughout a lifetime. In a study conducted in 2013, 1,066 patients aged 50 to 63 years with a history of premature aging (>10 years) were given 4033. The investigators used a combination of two different oral drugs to monitor the benefits of 4033. The first drug (T4) was taken for 24 days at a dose of 250 mg. The second drug (DMV15) was given to the same group for 24 days at 250 mg. The main endpoint of the study was the presence of muscle atrophy when compared to the placebo group. The researchers found that patients treated with 4033 were able to maintain higher levels of physical activity as a secondary outcome (which had a significant adverse effect) compared to those receiving placebo. For a total of 22 patients treated with 4033 (the drug alone or as part of a combination of drugs), the researchers found a significant increase in physical activity levels. The most dramatic improvements in physical activity seen in this analysis were in the legs: The patients receiving one-drug 4033 found an average increase in their leg exercise activity from 2.7 percent to 8.4 percent. In comparison, only one of the other 15 patients treated with the two-drug combination reported an increase in their leg activity. In this group, the improvement in leg activity rate was just 0.6 percent from baseline. This study is notable in that it shows that patients receiving the only-drug 4033 reported an improved health-related quality of life compared to patients receiving placebo. The researchers also did a follow-up of these patients at 2 years for a second analysis when they assessed the effects of 4033 on other health-related quality of life outcomes, such as walking, balance, respiratory rate, and cognition. In this analysis of the primary outcomes, patients treated with 4033 reported an average increase in these health-related quality of life outcomes from 7.1 percent to 24 percent. Compared to the placebo group, patients receiving 4033 also saw an average increase in their sleep duration of 2.4 hours, from an average of 9.6 hours to 12.0 hours. They also saw an average increase in their time spent in the activities of daily living (e.g., leisure time activities, daily activities), from 11.2 hours to 15.8 hours per week. They also saw an average increase in their time spent socializing Related Article: